Ficus erecta Thunb Leaves Alleviate Memory Loss Induced by Scopolamine in Mice via Regulation of Oxidative Stress and Cholinergic System.
Eunjin SohnYu Jin KimJoo-Hwan KimSoo-Jin JeongPublished in: Molecular neurobiology (2021)
We examined the neuropharmacological effects of ethanol extract of Ficus erecta Thunb leaves (EEFE) on cognitive dysfunction in a scopolamine (SCO)-induced memory impairment animal model. Memory impairment was measured using the Y-maze test and passive avoidance task (PAT). For 19 days, EEFE (100 or 200 mg/kg) was treated through oral administration. Treatment with EEFE ameliorated memory impairment in behavioral tests, along with significant protection from neuronal oxidative stress and neuronal cell loss in the brain tissues of SCO-injected mice. Antioxidant and neuroprotective effects of EEFE were further confirmed using in vitro assays. Our findings indicate that the mechanisms of neuroprotection and antioxidation of EEFE are regulated by the cholinergic system, promotion of cAMP response element-binding protein (CREB) phosphorylation, and the nuclear factor erythroid-2-related factor 2 (Nrf2)/heme oxygenase (HO)-1 signaling activation. The current study proposes that EEFE could be an encouraging plant resource and serve as a potent neuropharmacological drug candidate against neurodegenerative diseases.
Keyphrases
- oxidative stress
- diabetic rats
- cerebral ischemia
- nuclear factor
- working memory
- binding protein
- dna damage
- toll like receptor
- induced apoptosis
- ischemia reperfusion injury
- anti inflammatory
- high fat diet induced
- high throughput
- single cell
- high glucose
- type diabetes
- emergency department
- stem cells
- blood brain barrier
- immune response
- cell therapy
- signaling pathway
- skeletal muscle
- endothelial cells
- multiple sclerosis
- bone marrow
- resting state
- smoking cessation
- metabolic syndrome
- adverse drug