In silico Evaluation of a Vancomycin Dosing Guideline Among Adults with Serious Infections.

Critical care vancomycin dosing guidelines appeared slightly more effective than standard dosing, as per product information, in achieving PK-PD exposure associated with an increased likelihood of effectiveness. In addition, these guidelines significantly reduce the risk of subtherapeutic exposure. The risk of exceeding toxicity thresholds, however, was greater with the guidelines, and further investigation is suggested to improve dosing accuracy and sensitivity.