Incidence and clearance of anal human papillomavirus infection in 16 164 individuals, according to HIV status, gender, and male sexuality: an international pooled analysis of 34 longitudinal studies.
Feixue WeiMarc T GoodmanNing-Shao XiaJun ZhangAnna R GiulianoGypsyamber D'SouzaNancy A HessolMaarten F Schim van der LoeffJianghong DaiKarin NeukamAlexandra de PokomandyI Mary PoyntenRonald B GeskusJoaquin BurgosIsabelle EtienneyAnna Barbara MoscickiMaria Gabriella DonàMaura L GillisonAlan G NyitrayRebecca G NowakEvy YunihastutiHuachun ZouCarmen Hidalgo-TenorioNittaya PhanuphakJean Michel MolinaAlice M SchofieldStephen KerrSong FanYong LuJason J OngAdmire T ChikandiwaSirinya TeeraananchaiNicola SquillaceDorothy J WileyJoel M PalefskyDamien GeorgesCatharina J AlbertsGary M CliffordPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)
This robust and unifying analysis of anal hrHPV natural history is essential to designing and predicting the impact of HPV vaccination and HPV-based screening programmes on anal cancer prevention, particularly in MSM and PLWH. Importantly, it demonstrates the higher carcinogenic potential of longstanding anal prevalent hrHPV infection than more recent incident infection.