Clinical Management of Diffuse Low-Grade Gliomas.
Giuseppe LombardiValeria BarresiAntonella CastellanoEmeline TabouretFrancesco PasqualettiAlessandro SalvalaggioGiulia CerrettiMario CacceseMarta PadovanVittorina ZagonelTamara IusPublished in: Cancers (2020)
Diffuse low-grade gliomas (LGG) represent a heterogeneous group of primary brain tumors arising from supporting glial cells and usually affecting young adults. Advances in the knowledge of molecular profile of these tumors, including mutations in the isocitrate dehydrogenase genes, or 1p/19q codeletion, and in neuroradiological techniques have contributed to the diagnosis, prognostic stratification, and follow-up of these tumors. Optimal post-operative management of LGG is still controversial, though radiation therapy and chemotherapy remain the optimal treatments after surgical resection in selected patients. In this review, we report the most important and recent research on clinical and molecular features, new neuroradiological techniques, the different therapeutic modalities, and new opportunities for personalized targeted therapy and supportive care.
Keyphrases
- low grade
- high grade
- young adults
- radiation therapy
- end stage renal disease
- healthcare
- ejection fraction
- newly diagnosed
- chronic kidney disease
- induced apoptosis
- palliative care
- locally advanced
- peritoneal dialysis
- spinal cord injury
- patient reported outcomes
- quality improvement
- cell cycle arrest
- neuropathic pain
- dna methylation
- cell proliferation
- gene expression