RNA-binding protein CCDC137 activates AKT signaling and promotes hepatocellular carcinoma through a novel non-canonical role of DGCR8 in mRNA localization.

Shuang TaoShu-Juan XieLi-Ting DiaoGuo LvYa-Rui HouYan-Xia HuWan-Yi XuBin DuZhen-Dong Xiao

Published in: Journal of experimental & clinical cancer research : CR (2023)

Our results identify a critical proliferation-related role of CCDC137 and reveal a novel CCDC137/DGCR8/mRNA localization/AKT axis in HCC progression, which provide a potential target for HCC therapy.

Keyphrases

binding protein
signaling pathway
cell proliferation
genome wide
single cell
human health
dna methylation
bone marrow