Crizotinib-induced osteitis mimicking bone metastasis in a stage IV ALK-rearranged NSCLC patient: a case report.

Florian GuisierN PitonM BellefleurN DelbergheG AvenelE AngotO VittecoqM Ould-SlimaneH Morisse-PradierM SalaunL Thiberville

Published in: BMC cancer (2020)

This is the first report of crizotinib-induced osteitis. Crizotinib differs from other ALK inhibitors as it targets other kinases as well, which may have been responsible for the osteitis. Crizotinib can induce rapidly extensive osteitis, which can mimic tumor progression.

Keyphrases

advanced non small cell lung cancer
epidermal growth factor receptor
high glucose
diabetic rats
small cell lung cancer
drug induced
bone mineral density
oxidative stress
case report
soft tissue
bone loss