Effects of Anti-Tumor Necrosis Factor Therapy on Osteoblastic Activity at Sites of Inflammatory and Structural Lesions in Radiographic Axial Spondyloarthritis: A Prospective Proof-of-Concept Study Using Positron Emission Tomography/Magnetic Resonance Imaging of the Sacroiliac Joints and Spine.
Nils-Martin BruckmannChristoph RischplerStyliani TsiamiJulian KirchnerDaniel B AbrarTimo BartelJens TheysohnLale UmutluKen HerrmannWolfgang P FendlerChristian BuchbenderGerald AntochLino M SawickiAthanasios TsobanelisJuergen BraunXenofon BaraliakosPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2022)
Anti-TNF antibody treatment led to a significant decrease in osteoblastic activity within 3-6 months, especially, but not solely, at sites of inflammation. Larger data sets are needed for confirmation of the antiosteoblastic effects of TNFi for the prevention of radiographic progression in axial SpA.
Keyphrases
- positron emission tomography
- computed tomography
- magnetic resonance imaging
- rheumatoid arthritis
- oxidative stress
- vascular smooth muscle cells
- pet ct
- pet imaging
- disease activity
- electronic health record
- stem cells
- contrast enhanced
- systemic lupus erythematosus
- machine learning
- magnetic resonance
- cell therapy
- mesenchymal stem cells
- data analysis
- deep learning