Age-dependent involvement of gut mast cells and histamine in post-stroke inflammation.
Maria Pilar BlascoAnjali ChauhanPedram HonarpishehHilda AhnstedtJohn d'AigleArunkumar GanesanSriram AyyaswamyFrank BlixtSusan VenableAngela MajorDavid DurganAnthony HaagJulia KoflerRobert BryanLouise D McCulloughBhanu Priya GaneshPublished in: Journal of neuroinflammation (2020)
An important theme emerging from our results is that acute inflammatory events following ischemic insults in the brain persist longer in the aged mice when compared to younger animals. Taken together, our findings implicate mast cell activation and histamine signaling as a part of peripheral inflammatory response after ischemic stroke, which are profound in aged animals. Interfering with histamine signaling orally might provide translational value to improve stroke outcome.
Keyphrases
- inflammatory response
- atrial fibrillation
- oxidative stress
- cerebral ischemia
- liver failure
- lipopolysaccharide induced
- white matter
- respiratory failure
- resting state
- intellectual disability
- high fat diet induced
- multiple sclerosis
- toll like receptor
- aortic dissection
- autism spectrum disorder
- skeletal muscle
- metabolic syndrome
- functional connectivity
- extracorporeal membrane oxygenation