Myrindole A, an Antimicrobial Bis-indole from a Marine Sponge Myrmekioderma sp.
Philipp MoosmannTohru TaniguchiKazuo FurihataHiroaki UtsumiYuji IseYasuhiro MoriiNobuhiro YamawakiTomohiro TakataniOsamu ArakawaShigeru OkadaShigeki MatsunagaPublished in: Organic letters (2021)
Myrindole A, a bis-indole alkaloid, was isolated from the deep-sea sponge Myrmekioderma sp. The high degree of unsaturation of the molecule complicated the assignment of its structure by standard 2D-NMR experiments but was ultimately achieved by a combination of 1H-15N-HMBC and 1,n-ADEQUATE experiments as well as the comparison of measured and calculated CD spectra. Myrindole A showed antimicrobial activity against Gram-positive and Gram-negative bacteria.