Histone Deacetylase Inhibitor Panobinostat Benefits the Therapeutic Efficacy of Oncolytic Herpes Simplex Virus Combined with PD-1/PD-L1 Blocking in Glioma and Squamous Cell Carcinoma Models.

Yinglin WuXiaoqing ChenLei WangXusha ZhouYonghong LiuDongmei JiPeigen RenGrace Guoying ZhouJing Zhao

Published in: Viruses (2022)

Consequently, these data provide some new clues for the clinical development of combination therapy with OVs, epigenetic modifiers, and checkpoint blockades for glioma and squamous cell carcinoma.

Keyphrases

histone deacetylase
squamous cell carcinoma
combination therapy
herpes simplex virus
dna damage
lymph node metastasis
locally advanced
dna methylation
gene expression
electronic health record
cell cycle
big data
radiation therapy
machine learning
cell proliferation