Total Synthesis of Suillusin.

The first total synthesis of the fungal natural product suillusin is reported. The key features of the synthesis include a Michael-benzoin multicatalytic cascade that assembles the entire carbon framework in a single step, and a Rubottom-Swern oxidation sequence that yields the requisite diketone oxidation state of the core framework. This 10-step synthesis of suillusin will allow further evaluation of the biogenesis and the biological activity of the fungal metabolite.