Elevated matrix metalloproteinase-9 levels in neuronal extracellular vesicles in Alzheimer's disease.

These findings provide further support that levels of core pathological markers, including Aβ42 and P-T181-tau, are elevated in plasma NDEVs of patients with AD. Furthermore, MMP-9 might play an important role in the pathogenesis of AD, and is a promising inflammatory biomarker for AD.