SORL1 Polymorphisms in Mexican Patients with Alzheimer's Disease.

Danira Toral-RiosElizabeth Ruiz-SánchezNancy Lucero Martínez RodríguezMarlene Maury-RosilloRosas-Carrasco OscarFernando Becerril-PérezFrancisco Mena-BarrancoRosa Carvajal-GarcíaDaniela Silva-AdayaYair Delgado-NamoradoGerardo Ramos-PalaciosCarmen Sánchez-TorresVictoria Campos-Peña

Published in: Genes (2022)

ε4 allele and SORL1 variants could represent a genetic interaction effect that favors LOAD risk in the Mexican population. SNPs have been proposed as genetic markers associated with the development of LOAD that can support the clinical diagnosis. Future molecular studies could help understand sporadic Alzheimer's Disease (AD) among the Mexican population, where currently there is a sub-estimate number in terms of disease frequency and incidence.

Keyphrases

genome wide
copy number
cognitive decline
late onset
dna methylation
single molecule
mild cognitive impairment