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Mucin alleviates colonic barrier dysfunction by promoting spermine accumulation through enhanced arginine metabolism in Limosilactobacillus mucosae .

Xingjian ZhouQian XuXiangyu ZhangHao WangYu BaiYujun WuXiaoyi LiuZhenyu WangJie HuMingyi HuangYu PiJin Biao ZhaoJun-Jun WangDandan Han
Published in: mSystems (2024)
to produce spermine, suggesting that microbial-derived polyamines support a significant enhancement on the goblet cell proliferation and barrier function.
Keyphrases
  • cell proliferation
  • nitric oxide
  • microbial community
  • cell cycle
  • oxidative stress
  • ulcerative colitis
  • pi k akt
  • mouse model
  • amino acid