Tumor budding score predicts lymph node status in oral tongue squamous cell carcinoma and should be included in the pathology report.
Inger-Heidi BjerkliHelene LaurvikElisabeth Sivy NginamauTine M SølandDaniela CosteaHåkon HovLars Uhlin-HansenElin Hadler-OlsenSonja E SteigenPublished in: PloS one (2020)
Reclassification according to TNM8 shifted many tumors to a higher T-status, and also increased the prognostic value of the T-status. This supports the implementation of depth of invasion to the T-categorization in TNM8. Tumor budding correlated with lymph node metastases and survival. Therefore, information on tumor budding can aid clinicians in treatment planning and should be included in pathology reports of oral tongue squamous cell carcinomas.