MicroRNAs in Acute ST Elevation Myocardial Infarction-A New Tool for Diagnosis and Prognosis: Therapeutic Implications.
Alina Ioana ScărlătescuMiruna Mihaela MicheuNicoleta-Monica Popa-FoteaMaria DorobanțuPublished in: International journal of molecular sciences (2021)
Despite diagnostic and therapeutic advances, coronary artery disease and especially its extreme manifestation, ST elevation myocardial infarction (STEMI), remain the leading causes of morbidity and mortality worldwide. Early and prompt diagnosis is of great importance regarding the prognosis of STEMI patients. In recent years, microRNAs (miRNAs) have emerged as promising tools involved in many pathophysiological processes in various fields, including cardiovascular diseases. In acute coronary syndromes (ACS), circulating levels of miRNAs are significantly elevated, as an indicator of cardiac damage, making them a promising marker for early diagnosis of myocardial infarction. They also have prognostic value and great potential as therapeutic targets considering their key function in gene regulation. This review aims to summarize current information about miRNAs and their role as diagnostic, prognostic and therapeutic targets in STEMI patients.
Keyphrases
- st elevation myocardial infarction
- percutaneous coronary intervention
- acute coronary syndrome
- coronary artery disease
- end stage renal disease
- st segment elevation myocardial infarction
- ejection fraction
- newly diagnosed
- coronary artery bypass grafting
- cardiovascular disease
- peritoneal dialysis
- chronic kidney disease
- left ventricular
- prognostic factors
- climate change
- atrial fibrillation
- hepatitis b virus
- metabolic syndrome
- patient reported
- patient reported outcomes