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Doxorubicin concentrations in bone tumour-relevant tissues after bolus and continuous infusion: a randomized porcine microdialysis study.

Andrea René JørgensenMats BuePelle HanbergElisabeth Krogsgaard PetersenChristina HarlevJakob HansenThomas Baad-HansenAkmal SafwatMaiken Stilling
Published in: Cancer chemotherapy and pharmacology (2024)
The pharmacokinetic profile for doxorubicin in the investigated tissues is very similar when comparing bolus and 6 h continuous infusion.
Keyphrases
  • gene expression
  • drug delivery
  • low dose
  • cancer therapy
  • soft tissue
  • atomic force microscopy
  • high resolution
  • bone loss