Network Pharmacology and Experimental Validation to Reveal Effects and Mechanisms of Icariin Combined with Nobiletin against Chronic Obstructive Pulmonary Diseases.

Ruilong LuKexin XuYanqin QinXuejie ShaoMiaomiao YanYixi LiaoBo WangJie ZhaoJiansheng LiYan-Ge Tian

Published in: Evidence-based complementary and alternative medicine : eCAM (2022)

Icariin combined with nobiletin has therapeutic effects on COPD by inhibiting inflammation. The potential mechanisms of I&N may relate to the MAPK pathway and PI3K-Akt pathway.

Keyphrases

signaling pathway
oxidative stress
chronic obstructive pulmonary disease
pulmonary hypertension
lung function
single cell
gene expression
risk assessment
human health
cell proliferation