Anti-inflammatory Effects of Empagliflozin and Gemigliptin on LPS-Stimulated Macrophage via the IKK/NF-κB, MKK7/JNK, and JAK2/STAT1 Signalling Pathways.

Nami LeeYu Jung HeoSung-E ChoiJa Young JeonSeung Jin HanDae Jung KimYup KangKwan Woo LeeHae Jin Kim

Published in: Journal of immunology research (2021)

Our study demonstrated the anti-inflammatory effects of empagliflozin and gemigliptin via IKK/NF-κB, MKK7/JNK, and JAK2/STAT1 pathway downregulation in macrophages. In all cases, combined empagliflozin and gemigliptin treatment showed greater anti-inflammatory properties.

Keyphrases

anti inflammatory
signaling pathway
pi k akt
induced apoptosis
lps induced
cell death
oxidative stress
inflammatory response
nuclear factor
cell proliferation
endoplasmic reticulum stress