TP53 mutant cell lines selected for resistance to MDM2 inhibitors retain growth inhibition by MAPK pathway inhibitors but a reduced apoptotic response.

Chiao-En WuTsin Shue KoayYi-Hsuan HoPenny LovatJohn Lunec

Published in: Cancer cell international (2019)

The TP53MUT cells selected by resistance to MDM2 inhibitors nevertheless retained growth inhibitory but not apoptotic response to MAPK pathway inhibitors.

Keyphrases

cell death
signaling pathway
induced apoptosis
oxidative stress
cell cycle arrest
pi k akt
anti inflammatory
endoplasmic reticulum stress
wild type