Coronary Computed Tomography Angiography Derived Fractional Flow Reserve and Plaque Stress.
Bjarne Linde NørgaardJonathon LeipsicBon-Kwon KooChristopher K ZarinsJesper Møller JensenNiels Peter SandCharles A TaylorPublished in: Current cardiovascular imaging reports (2016)
Fractional flow reserve (FFR) measured during invasive coronary angiography is an independent prognosticator in patients with coronary artery disease and the gold standard for decision making in coronary revascularization. The integration of computational fluid dynamics and quantitative anatomic and physiologic modeling now enables simulation of patient-specific hemodynamic parameters including blood velocity, pressure, pressure gradients, and FFR from standard acquired coronary computed tomography (CT) datasets. In this review article, we describe the potential impact on clinical practice and the science behind noninvasive coronary computed tomography (CT) angiography derived fractional flow reserve (FFRCT) as well as future applications of this technology in treatment planning and quantifying forces on atherosclerotic plaques.
Keyphrases
- computed tomography
- coronary artery
- coronary artery disease
- image quality
- positron emission tomography
- dual energy
- clinical practice
- percutaneous coronary intervention
- coronary artery bypass grafting
- magnetic resonance imaging
- contrast enhanced
- aortic stenosis
- heart failure
- high resolution
- magnetic resonance
- current status
- aortic valve
- left ventricular
- acute coronary syndrome
- transcatheter aortic valve replacement
- virtual reality