Association of type 2 diabetes mellitus with dementia-related and non-dementia-related mortality among postmenopausal women: A secondary competing risks analysis of the women's health initiative.
Tyler J TitcombPhyllis RicheyRamon CasanovaLawrence S PhillipsSimin LiuShama D KaranthNazmus SaquibTomas NuñoJoAnn E MansonAladdin H ShadyabLongjian LiuTerry L WahlsLinda G SnetselaarRobert B WallaceWei BaoPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)
Type 2 diabetes mellitus is more strongly associated with Alzheimer's disease (AD)/AD and related dementias (ADRD) mortality compared to the competing risk of non-AD/ADRD mortality among postmenopausal women. This relationship was consistent for AD and ADRD, respectively. This association is strongest among participants without obesity or hypertension and with younger age at baseline, higher diet quality, higher physical activity, higher alcohol consumption, and older age at the time of diagnosis of type 2 diabetes mellitus.
Keyphrases
- postmenopausal women
- bone mineral density
- physical activity
- alcohol consumption
- cardiovascular events
- mild cognitive impairment
- risk factors
- blood pressure
- weight loss
- healthcare
- cognitive impairment
- metabolic syndrome
- type diabetes
- insulin resistance
- cognitive decline
- polycystic ovary syndrome
- human health
- adipose tissue
- pregnant women
- risk assessment
- middle aged
- community dwelling