Plasma acetyl-l-carnitine and l-carnitine in major depressive episodes: a case-control study before and after treatment.

Abd El Kader Ait TayebRomain ColleKhalil El-AsmarKenneth ChappellCécile Acquaviva-BourdainDenis J DavidSéverine TrabadoPhilippe ChansonBruno FeveLaurent BecquemontCéline VerstuyftEmmanuelle Corruble

Published in: Psychological medicine (2021)

Our data suggest a decreased mitochondrial metabolism of l-carnitine into ALC during MDE. This decreased mitochondrial metabolism is restored after a 6-month antidepressant treatment. Moreover, the magnitude of mitochondrial dysfunction may predict remission after 3 months of antidepressant treatment. New strategies targeting mitochondria should be explored to improve treatments of MDD.

Keyphrases

major depressive disorder
bipolar disorder
cell death
rheumatoid arthritis
electronic health record
big data
cancer therapy
disease activity
replacement therapy
deep learning
data analysis