Preparation and Characterization of Silymarin-Conjugated Gold Nanoparticles with Enhanced Anti-Fibrotic Therapeutic Effects against Hepatic Fibrosis in Rats: Role of MicroRNAs as Molecular Targets.
Abdullah Saad AbdullahIbrahim El Tantawy El SayedAbdel Moneim A El-TorgomanNoweir Ahmad AlghamdiSami UllahWageh SwelmMaher Abd El Naby KamelPublished in: Biomedicines (2021)
The successful synthesis of SGNPs with sizes ranging from 16 up to 20 nm and entrapment efficiency and loading capacity 96% and 38.69%, respectively. In vivo studies revealed that the obtained nano-formulation of SIL boosted its anti-fibrotic effects.