Single-cell analysis reveals fibroblast heterogeneity and myofibroblasts in systemic sclerosis-associated interstitial lung disease.
Eleanor ValenziMelissa BulikTracy TabibChristina MorseJohn SembratHumberto Trejo BittarMauricio RojasRobert LafyatisPublished in: Annals of the rheumatic diseases (2019)
Our results demonstrate previously unrecognised fibroblast heterogeneity in SSc-ILD and healthy lungs, and define multimodal transcriptome-phenotypes associated with these populations. Our data indicate that myofibroblast differentiation and proliferation are key pathological mechanisms driving fibrosis in SSc-ILD.
Keyphrases
- interstitial lung disease
- single cell
- systemic sclerosis
- rna seq
- high throughput
- rheumatoid arthritis
- idiopathic pulmonary fibrosis
- signaling pathway
- electronic health record
- transforming growth factor
- big data
- pain management
- gene expression
- epithelial mesenchymal transition
- genome wide
- machine learning
- liver fibrosis