The feedback loop of EFTUD2/c-MYC impedes chemotherapeutic efficacy by enhancing EFTUD2 transcription and stabilizing c-MYC protein in colorectal cancer.

Xiaojian ZhuChangxue LiYunfei GaoQingyuan ZhangTao WangHuaixiang ZhouFanqin BuJia ChenXinjun MaoYulong HeKaiming WuNingning LiHongliang Luo

Published in: Journal of experimental & clinical cancer research : CR (2024)

Our findings revealed a positive feedback loop involving an EFTUD2/c-MYC axis that hampers the efficacy of 5-FU chemotherapy in CRC cells by increasing EFTUD2 transcription and stabilizing c-MYC oncoprotein. This study highlights the potential of EFTUD2 as a promising therapeutic target to surmount chemotherapy resistance in CRC patients.

Keyphrases

transcription factor
end stage renal disease
induced apoptosis
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
peritoneal dialysis
radiation therapy
amino acid
cell proliferation
protein protein