Age-related alteration in characteristics, function, and transcription features of ADSCs.
Keya LiGuiying ShiXuepei LeiYiying HuangXinyue LiLin BaiChuan QinPublished in: Stem cell research & therapy (2021)
ADSCs from old donors have some age-related alterations. The CCL7-CCL2-CCR2 axis is a potential target for gene therapy to reduce the harmful effects of ADSCs from old donors. To improve on autologous transplantation, we would recommend that ADSCs should be cryopreserved in youth with a minimum number of passages or block CCL7-CCL2-CCR2 to abolish the effects of age-related alterations in ADSCs through the Chemokine signaling pathway.
Keyphrases
- liver fibrosis
- gene therapy
- liver injury
- signaling pathway
- drug induced
- dendritic cells
- regulatory t cells
- physical activity
- mental health
- bone marrow
- kidney transplantation
- young adults
- epithelial mesenchymal transition
- transcription factor
- stem cells
- climate change
- risk assessment
- platelet rich plasma
- mesenchymal stem cells
- endoplasmic reticulum stress