A single-cell atlas of bovine skeletal muscle reveals mechanisms regulating intramuscular adipogenesis and fibrogenesis.

Leshan WangPeidong GaoChaoyang LiQianglin LiuZeyang YaoYuxia LiXujia ZhangJiangwen SunConstantine SimintirasMatthew WelbornKenneth McMillinStephanie OprescuShihuan KuangXing Fu

Published in: Journal of cachexia, sarcopenia and muscle (2023)

Our study demonstrates the feasibility of beef cattle as a model for studying IMF and IMC. We illustrate the FAP programming during intramuscular adipogenesis and fibrogenesis and reveal the reliability of CFD as a predictor and biomarker of IMF accumulation in cattle and humans.

Keyphrases

single cell
skeletal muscle
rna seq
high throughput
insulin resistance
high fat diet induced
genome wide
gene expression
type diabetes
metabolic syndrome
dna methylation