Synthesis of Diverse Aromatic Ketones through C-F Cleavage of Trifluoromethyl Group.
Mai IkedaTsubasa MatsuzawaTakamoto MoritaTakamitsu HosoyaSuguru YoshidaPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2020)
An efficient synthetic method of aromatic ketones through C-F cleavage of trifluoromethyl group is disclosed. The high functional group tolerance of the transformation and the remarkable stability of trifluoromethyl group in various reactions enabled multi-substituted aromatic ketone synthesis in an efficient route involving useful transformations such as ortho-lithiation, aryne chemistry, and cross-couplings.
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