Confirmation of Di(2-ethylhexyl) phthalate-induced micronuclei by repeated dose liver micronucleus assay: focus on evaluation of liver micronucleus assay in young rats.
Miyuki ShiganoRie TakashimaKensuke SatomotoHenri SalesRyoko HaradaShuichi HamadaPublished in: Genes and environment : the official journal of the Japanese Environmental Mutagen Society (2024)
The detection of DEHP-induced micronuclei by the RDLMN assay suggests that this assay could detect the potential genotoxicity and hepatocarcinogenicity of DEHP. It also demonstrated the utility of the RDLMN assay in identifying metabolically activated hepatic carcinogens.