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Breakthrough SARS-CoV-2 Infections after Vaccination in North Carolina.

Diane UschnerMatthew BottWilliam H LagardeJoseph KeatingHazel TappAndrea A BerryAustin L SealsIqra MunawarJohn S SchieffelinJoshua YukichMichele SantacatterinaMihili GunaratneLida M FetteBrian BurkeGreg StrylewiczSharon L EdelsteinAmina AhmedKristen MillerJohn W SandersDavid HerringtonWilliam S WeintraubMichael S Runyonnull On Behalf Of The Covid-Community Research Partnership
Published in: Vaccines (2022)
We characterize the overall incidence and risk factors for breakthrough infection among fully vaccinated participants in the North Carolina COVID-19 Community Research Partnership cohort. Among 15,808 eligible participants, 638 reported a positive SARS-CoV-2 test after vaccination. Factors associated with a lower risk of breakthrough in the time-to-event analysis included older age, prior SARS-CovV-2 infection, higher rates of face mask use, and receipt of a booster vaccination. Higher rates of breakthrough were reported by participants vaccinated with BNT162b2 or Ad26.COV2.S compared to mRNA-1273, in suburban or rural counties compared to urban counties, and during circulation of the Delta and Omicron variants.
Keyphrases
  • sars cov
  • respiratory syndrome coronavirus
  • healthcare
  • mental health
  • risk factors
  • tertiary care
  • coronavirus disease
  • copy number
  • physical activity
  • south africa
  • gene expression
  • dna methylation
  • binding protein