Vagus nerve stimulation inhibits cortical spreading depression via glutamate-dependent TrkB activation mechanism in the nucleus tractus solitarius.

Tzu-Ting LiuShih-Pin Chen Shuu-Jiun WangJiin-Cherng Yen

Published in: Cephalalgia : an international journal of headache (2024)

VNS induces the activation of glutamate receptor-mediated TrkB signaling in the NTS, which might modulate serotonergic and norepinephrinergic innervation to the cerebral cortex to inhibit CSD and cortical inflammation.

Keyphrases

oxidative stress
depressive symptoms
subarachnoid hemorrhage
functional connectivity
sleep quality
brain injury