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Evaluation of the routine use of E-cadherin immunohistochemistry in the typing of breast carcinomas: results of a randomized diagnostic study.

Gábor CserniEndre KálmánNóra UdvarhelyiEszter PappIsabel GroteStephan BartelsMatthias ChristgenHans KreipeJanina Kulka
Published in: Histopathology (2023)
The routine use of E-cadherin IHC decreases the uncertainty in typing and improves the typing accuracy at the cost of potentially redundant additional immunostains. Furthermore, this procedure does not exclude uncertainty due to E-cadherin-positive ILCs, which are occasionally difficult to confidently label as ILC, especially when the growth pattern is not classic.
Keyphrases
  • genetic diversity
  • clinical practice
  • high grade
  • minimally invasive