Phosphatidylinositol 3-kinase delta pathway: a novel therapeutic target for Sjögren's syndrome.

Saba NayarJoana CamposCharlotte G SmithValentina IannizzottoDavid H GardnerSerena ColafrancescoElena PipiFlorian KollertKelly J HunterCharlotte BrewerChristopher Dominic BuckleySimon J BowmanRoberta PrioriGuido ValesiniMaria JuarezWilliam A FahyBenjamin A FisherAndrew PayneRodger A AllenFrancesca Barone

Published in: Annals of the rheumatic diseases (2018)

These data demonstrate activation of PI3Kδ pathway within the glands of patients with pSS and its contribution to disease pathogenesis in a model of disease, supporting the exploration of the therapeutic potential of PI3Kδ pathway inhibition in this condition.

Keyphrases

protein kinase
electronic health record
case report
big data
disease activity
deep learning