Proinflammatory Signature of the Dysfunctional Endothelium in Pulmonary Hypertension. Role of the Macrophage Migration Inhibitory Factor/CD74 Complex.

Morane Le HiressLy TuNicolas RicardCarole PhanRaphaël ThuilletElie FadelPeter DorfmüllerDavid MontaniFrances de ManMarc HumbertAlice HuertasChristophe Guignabert

Published in: American journal of respiratory and critical care medicine (2016)

We report here that CD74 and MIF are markedly increased and activated in patients with iPAH, contributing to the abnormal proinflammatory phenotype of pulmonary ECs in iPAH.

Keyphrases

pulmonary hypertension
pulmonary artery
pulmonary arterial hypertension
nitric oxide
nk cells
adipose tissue
coronary artery