AQX-1125, small molecule SHIP1 activator inhibits bleomycin-induced pulmonary fibrosis.

Jennifer CrossGrant R StentonCurtis HarwigCsaba SzabóTiziana GenoveseRosanna Di PaolaEmanuale EspositoSalvatore CuzzocreaLloyd F Mackenzie

Published in: British journal of pharmacology (2017)

AQX-1125 prevented bleomycin-induced lung injury during the inflammatory and fibrotic phases. AQX-1125, given therapeutically, modified disease progression and improved survival, as effectively as pirfenidone.

Keyphrases

pulmonary fibrosis
small molecule
high glucose
diabetic rats
idiopathic pulmonary fibrosis
systemic sclerosis
inflammatory response