IgE promotes type 2 innate lymphoid cells in murine food allergy.

Oliver T BurtonJ Medina TamayoA J StranksS MillerK J KoleoglouE O WeinbergH C Oettgen

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2018)

These findings support an important role for IgE-activated mast cells in driving intestinal ILC2 expansion in food allergy and reveal that ILC2, in turn, can enhance responsiveness to the mediators of anaphylaxis produced by mast cells. Strategies designed to inhibit IgE signalling or mast cell activation are likely to inhibit both type 2 immunity and immediate hypersensitivity in food allergy.

Keyphrases

induced apoptosis
cell cycle arrest
genome wide
single cell
cell death
gene expression
endoplasmic reticulum stress
dna methylation
fluorescent probe
single molecule
pi k akt
allergic rhinitis