Claudin-2 Mediates the Proximal Tubular Epithelial Cell-Fibroblast Crosstalk via Paracrine CTGF.

Congcong Guo Mingwen JiaoYuying CuiPingjiang LiJinming YaoJianjun DongJianjun Dong

Published in: Diabetes, metabolic syndrome and obesity : targets and therapy (2024)

Our study suggested that Claudin-2 in PTECs, a key mediator of paracellular cation and water transport, promotes the activation and proliferation of surrounding fibroblasts significantly via CTGF in a paracrine manner.

Keyphrases

ionic liquid
extracellular matrix
endothelial cells
high glucose
wound healing