Multi-ancestry phenome-wide association of complement component 4 variation with psychiatric and brain phenotypes in youth.

Leanna M HernandezMinsoo KimPan ZhangRichard A I BethlehemGil HoftmanRobert LoughnanDiana SmithSusan Y BookheimerChun Chieh FanCarrie E BeardenWesley K ThompsonMichael J Gandal

Published in: Genome biology (2023)

Our results suggest neurodevelopmental effects of C4A on childhood medial temporal lobe structure, which may serve as a biomarker for schizophrenia risk prior to symptom onset.

Keyphrases

mental health
bipolar disorder
white matter
resting state
physical activity
young adults
functional connectivity
early life
multiple sclerosis
childhood cancer
congenital heart disease
genome wide association study
subarachnoid hemorrhage