Liposomal formulation of a gold(III) metalloantibiotic: a promising strategy against antimicrobial resistance.
Alejandro LlamedoPablo RodríguezYaiza GabasaRaquel G SoengasHumberto Rodríguez-SollaDavid ElorriagaFrancisco J García-AlonsoSara M SotoPublished in: Dalton transactions (Cambridge, England : 2003) (2024)
A novel lipoformulation was developed by encapsulating cationic (S^C)-cyclometallated gold(III) complex [Au(dppta)(N 2 Py-PZ-dtc)] + (AuPyPZ) in liposomes. The liposomal form of compound AuPyPZ has a bactericidal action similar to that of the free drug without any appreciable effect on the viability of mammalian cells. Furthermore, the nanoformulation reduces metalloantibiotic-induced inhibition of hERG and the inhibition of cytochromes, significantly decreasing the potential liabilities of the metallodrug. The obtained metalloantibiotic liposomal formulation shows high stability and suitable properties for drug delivery, representing an effective strategy to fight against drug-resistant bacteria.
Keyphrases
- drug delivery
- drug resistant
- antimicrobial resistance
- multidrug resistant
- acinetobacter baumannii
- cancer therapy
- drug release
- high glucose
- drug induced
- silver nanoparticles
- diabetic rats
- sensitive detection
- reduced graphene oxide
- human health
- climate change
- risk assessment
- oxidative stress
- endothelial cells
- quantum dots
- gold nanoparticles
- visible light
- stress induced