TRPM2 in the Brain: Role in Health and Disease.
Giulia SitaRaffaella ArfèAgnese GraziosiGloria RavegniniFabiana MorroniPublished in: Cells (2018)
Transient receptor potential (TRP) proteins have been implicated in several cell functions as non-selective cation channels, with about 30 different mammalian TRP channels having been recognized. Among them, TRP-melastatin 2 (TRPM2) is particularly involved in the response to oxidative stress and inflammation, while its activity depends on the presence of intracellular calcium (Ca2+). TRPM2 is involved in several physiological and pathological processes in the brain through the modulation of multiple signaling pathways. The aim of the present review is to provide a brief summary of the current insights of TRPM2 role in health and disease to focalize our attention on future potential neuroprotective strategies.
Keyphrases
- oxidative stress
- cerebral ischemia
- public health
- healthcare
- human health
- resting state
- mental health
- white matter
- signaling pathway
- health information
- working memory
- single cell
- dna damage
- functional connectivity
- subarachnoid hemorrhage
- risk assessment
- health promotion
- cell therapy
- current status
- blood brain barrier
- pi k akt
- mesenchymal stem cells
- diabetic rats
- binding protein