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Insufficiency of ventral hippocampus to medial prefrontal cortex transmission explains antidepressant non-response.

Mariusz PappPiotr GrucaMagdalena LasonEwa LitwaWojciech SoleckiPaul Willner
Published in: Journal of psychopharmacology (Oxford, England) (2021)
The synergism between VEN and vHPC-mPFC OGS supports the hypothesis that the antidepressant non-responsiveness of WKY rats results from a failure of antidepressant treatment fully to restore transmission in the vHPC-mPFC pathway.
Keyphrases
  • prefrontal cortex
  • major depressive disorder
  • spinal cord
  • cognitive impairment