Virulence factors impair epithelial junctions during bacterial infection.
Manxi ZhengShuang SunJun ZhouMin LiuPublished in: Journal of clinical laboratory analysis (2020)
Epithelial cells are typically connected through different types of cell junctions that are localized from the apical membrane to the basal surface. In this way, epithelium cells form the first barrier against pathogenic microorganisms and prevent their entry into internal organs and the circulatory system. Recent studies demonstrate that bacterial pathogens disrupt epithelial cell junctions through targeting junctional proteins by secreted virulence factors. In this review, we discuss the diverse strategies used by common bacterial pathogens, including Pseudomonas aeruginosa, Helicobacter pylori, and enteropathogenic Escherichia coli, to disrupt epithelial cell junctions during infection. We also discuss the potential of targeting the pathogenic mechanisms in the treatment of pathogen-associated diseases.
Keyphrases
- pseudomonas aeruginosa
- helicobacter pylori
- escherichia coli
- single molecule
- biofilm formation
- antimicrobial resistance
- cystic fibrosis
- helicobacter pylori infection
- staphylococcus aureus
- induced apoptosis
- cancer therapy
- gram negative
- candida albicans
- cell cycle arrest
- klebsiella pneumoniae
- cell therapy
- cell death
- signaling pathway
- bone marrow
- risk assessment
- case control
- multidrug resistant
- smoking cessation