CTNND1 is involved in germline predisposition to early-onset gastric cancer by affecting cell-to-cell interactions.
Cristina Herrera-ParienteLaia BonjochJenifer MuñozGuerau FernàndezYasmin Soares de LimaRomesa MahmoodMiriam CuatrecasasTeresa OcañaSandra Lopez-PradesGemma Llargués-SistacXavier Domínguez-RoviraJoan LlachIrina LuzkoMarcos Díaz-GayConxi LazaroJoan BrunetCarmen Castillo-ManzanoMaría Asunción García-GonzálezAngel LanasMarta CarrilloRaquel Hernández San GilEnrique QuinteroNuria SalaGemma LlortLara AguileraLaura CarotPilar Diez-RedondoRodrigo JoverTeresa Ramon Y CajalJoaquín CubiellaAntoni CastellsFrancesc BalaguerLuis BujandaSergi Castellví-BelLeticia MoreiraPublished in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2024)
Defects in CTNND1 could be involved in germline predisposition to gastric cancer by altering E-cadherin and, consequently, cell-to-cell interactions. In the present study, CTNND1 germline variants explained 2% (3/172) of the cases, although further studies in larger external cohorts are needed.