N-Heterocyclic Carbene (NHC) Organocatalytic One-Pot Reaction for the Enantioselective Synthesis of Fluoromethylated Chromenones.
Baoxu WangLiangsen HuangYuchen HouShouang LanJiajia ChengPublished in: Organic letters (2018)
An efficient carbene organocatalyzed route to enantioenriched chromenones, bearing one tri- or difluoromethylated stereogenic center in the β position of the carbonyl group, from o-allyloxybenzaldehydes is described. The one-pot transition-metal-free transformation exhibits a broad substrate scope and excellent enantioselectivity.
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