Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer.
Ludovic BaraultAlessio AmatuGiulia SiravegnaAgostino PonzettiSebastian MoranAndrea CassingenaBenedetta MussolinChiara FalcomatàAlexandra M BinderCarmen CristianoDaniele OddoSimonetta GuarreraCarlotta CancelliereSara BustreoKatia BencardinoSean MadenAlice VanzatiPatrizia ZavattariGiuseppe MatulloMauro TruiniWilliam M GradyPatrizia RaccaKarin B MichelsSalvatore SienaManel EstellerAlberto BardelliAndrea Sartore-BianchiFederica Di NicolantonioPublished in: Gut (2017)
This five-gene methylation panel can be used to circumvent the absence of patient-specific mutations for monitoring tumour burden dynamics in liquid biopsy under different therapeutic regimens. This method might be proposed for assessing pharmacodynamics in clinical trials or when conventional imaging has limitations.
Keyphrases
- metastatic colorectal cancer
- clinical trial
- genome wide
- high resolution
- small molecule
- circulating tumor
- dna methylation
- cell free
- high throughput
- single molecule
- ultrasound guided
- ionic liquid
- gene expression
- fine needle aspiration
- transcription factor
- single cell
- mass spectrometry
- genome wide identification
- double blind
- genome wide analysis