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N-Heterocyclic imino-catalyzed 1,4-regioselective azide-alkyne cycloaddition (AAC): a metal-free approach.

Shanmugam RevathiAditya L ShindeMulimani K RajashekharDebasish MandalAmit Ranjan MaitySomenath GaraiTapas Ghatak
Published in: Chemical communications (Cambridge, England) (2023)
An unprecedented synthetic approach has been devised to efficiently synthesize regioselective 1,4-disubstituted 1,2,3-triazoles. This technique relies on the use of innovative metal-free highly basic N-heterocyclic imino catalysts. The experimental observations have been supported further by TD-DFT computational studies.
Keyphrases
  • highly efficient
  • room temperature
  • density functional theory
  • molecular docking
  • case control
  • transition metal
  • metal organic framework
  • molecular dynamics
  • ionic liquid