Areca nut-induced metabolic reprogramming and M2 differentiation promote OPMD malignant transformation.
Shyng-Shiou F YuanLeong-Perng ChanHieu D H NguyenChang-Wei SuYuk-Kwan ChenJeff Yi-Fu ChenShigetaka ShimodairaStephen Chu-Sung HuSteven LoYen-Yun WangPublished in: Journal of experimental & clinical cancer research : CR (2024)
Our study provides novel mechanisms for areca nut-induced oral carcinogenesis, demonstrating that areca nut promotes M2 macrophage differentiation and secretion of oncogenic cytokines that critically activate malignant transformation of oral premalignant cells.