Warburg effect enhanced by AKR1B10 promotes acquired resistance to pemetrexed in lung cancer-derived brain metastasis.

Wenzhe DuanWenwen LiuShengkai XiaYang ZhouMengyi TangMingxin XuManqing LinXinyu LiQi Wang

Published in: Journal of translational medicine (2023)

Our finding demonstrates that AKR1B10/glycolysis/H4K12la/CCNB1 promotes acquired PEM chemoresistance in lung cancer BM, providing novel strategies to sensitize PEM response in the treatment of lung cancer patients suffering from BM.

Keyphrases

small cell lung cancer
resting state
white matter
advanced non small cell lung cancer
functional connectivity
combination therapy
blood brain barrier
brain injury