Marrow-Infiltrating Regulatory T Cells Correlate with the Presence of Dysfunctional CD4+PD-1+ Cells and Inferior Survival in Patients with Newly Diagnosed Multiple Myeloma.

Nouf AlrasheedLydia LeeEhsan GhoraniJake Y HenryLucia CondeMelody ChinDaria Galas-FilipowiczAndrew J S FurnessSelina J ChavdaHuw RichardsDunnya De-SilvaOliver C CohenDominic PatelAnthony BrooksManuel Rodriguez-JustoMartin PuleJavier HerreroSergio A QuezadaKwee L Yong

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

BM-infiltrating T-cell subsets, specifically Tregs and PD-1-expressing CD4 effectors, negatively influence clinical outcomes in newly diagnosed patients. Pending confirmation in larger cohorts and further mechanistic work, these immune parameters may inform new risk models, and present potential targets for immunotherapeutic strategies.

Keyphrases

newly diagnosed
regulatory t cells
multiple myeloma
induced apoptosis
dendritic cells
end stage renal disease
ejection fraction
chronic kidney disease
immune response
cell cycle arrest
peripheral blood
risk assessment
prognostic factors
nk cells
cell proliferation
climate change
free survival
patient reported